*Refers to symptoms associated with menopause and perimenopause studied for Siberian Rhubarb, including hot flushes, restless sleep, fatigue, muscle soreness, irritability and vaginal dryness.
Shatavari (Asparagus racemosus)
Kumari P, Khargekar NC, Saini V, et al. Efficacy and Safety of Shatavari Root Extract for the Management of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study. PubMed. 2024 Apr 8.
Naseri R, Farnia V, Yazdchi K, et al. Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study. Korean J Fam Med. 2019 Nov;40(6):362-367.
Vollmer G, Papke A, Zierau O. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Chin Med. 2010 Feb 19;5:7.
Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64.
Santoro N. Perimenopause: From Research to Practice. J Womens Health (Larchmt). 2016 Apr;25(4):332-9. doi: 10.1089/jwh.2015.5556. Epub 2015 Dec 10. PMID: 26653408; PMCID: PMC4834516.
Avis NE, Crawford SL, Greendale G, et al. Duration of menopause vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015 Apr;175(4):531-539.
Baber RJ, Panay N, Fenton A, IMS Writing Group. 2022 International Menopause Society recommendations on menopausal hormone therapy and preventive strategies for midlife health. Climacteric. 2022 Apr;25(2):132-153.
Babicki A, Szostek M, Mastalerz-Migas A. Quality of clinical practice guidelines for menopause: A systematic review and critical appraisal. Maturitas. 2024 Mar;185:107811.
Deole YS, Thakar AB, Thatte UM, et al. Understanding the Role of Shatavari (Asparagus racemosus) in Enhancing Female Fertility: a Traditional Perspective. Int J Ayurveda Pharm Res. 2025;13(3):104-110.
Chasteberry (Vitex agnus-castus)
Csupor D, Bácsi A, Gál E, et al. Vitex agnus-castus in premenstrual syndrome: A meta-analysis. Phytomedicine. 2019 Dec 25;62:152947.
Schellenberg R, Zimmermann C, Drewe J. Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome. Reprod Endocrinol. 2016;(30):111–118.
Affron® Saffron
Lopresti AL, Smith SJ, Metse AP, Drummond PD. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun 15;16(6):937–947.
Siberian Rhubarb (Rheum rhaponticum)
Shah J, Gudadhe J, Tiwari P, et al. Evaluation of the Efficacy and Safety of Rheum rhaponticum Root Extract (ERr 731) for Menopausal Symptoms in Perimenopausal Indian Women: An Interim Analysis. J Midlife Health. 2021;12(2):108-115.
Hasper I, Roth-Ehrang R, Becker T, et al. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009;16:117–131.