Cognitive Wellbeing

Optimising Ashwagandha for Improved Stress Response

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Ashwagandha is an adaptogenic herb known for its many health benefits, particularly in stress reduction and cognitive support. In Ayurvedic medicine, ashwagandha is considered a Rasayana, meaning that it helps maintain youth, both mentally and physically. Its historical usage in traditional medicine has spurred investigations into its therapeutic potential and healing capabilities. NooGanda is a groundbreaking, research supported liposomal Ashwagandha with a unique compound composition, shown to have benefits, different from any other ashwagandha in the world.

Understanding Ashwagandha and Adaptogens

Ashwagandha, scientifically known as Withania somnifera, Indian Ginseng and Indian Winter Cherry, is an ancient medicinal herb native to India and North Africa. It has been a staple in Ayurvedic medicine for thousands of years, valued for its adaptogenic properties and wide-ranging health benefits. Historically, ashwagandha has been used as an adaptogen helping to combat stress, increase energy levels, and improve concentration. It's also been used to enhance physical endurance and promote longevity. 

What are Adaptogens?

Adaptogens, are a class of herbs, roots, and fungi known for their ability to help the body adapt to stressors, both physical and mental. They work by modulating the body's stress response system, particularly the hypothalamic-pituitary-adrenal (HPA) axis and the sympathoadrenal system, enhancing the body's resilience to stress by reducing the negative impact of stressors on bodily functions. By doing so, adaptogens promote balance, equilibrium, and homeostasis within the body.

Ashwagandha, specifically, has been extensively studied for its adaptogenic properties. Research suggests that it can reduce cortisol levels, modulate the immune system, and improve overall well-being. It has also been investigated for its potential benefits in managing anxiety, depression, and cognitive function (2). 

However, studies have shown that the bioavailability (the amount of a compound that reaches circulation to exert effects) of standard ashwagandha is limited due to rapid metabolism by the microbiota and the liver, making it difficult to deliver a high concentration therapeutic dose. This is where NooGandha is different.

The Science Behind NooGanda's Liposomal Delivery System

NooGanda uses an innovative liposomal delivery system to enhance the absorption and bioavailability of ashwagandha. Liposomes are tiny vesicles made up of phospholipids, similar to the cell membranes in our bodies. They encapsulate the active ingredients of ashwagandha, allowing them to bypass the harsh conditions of the digestive system and be efficiently transported across cell membranes. This improves their efficacy by delivering a higher concentration of ashwagandha to target tissues, resulting in enhanced therapeutic effects. 

Additionally, NooGandha contains a high concentration of distinct compounds, enabling it to perform differently than other ashwagandha extracts. This innovative approach identifies and selects only compounds with elevated nootropic (cognitive enhancers) bioactivity and bioavailability to promote cognitive performance and minimize stress, while reducing compounds may be overly sedating.

Unveiling the Benefits of NooGanda

NooGanda offers a multitude of potential benefits, including stress reduction, cognitive support, energy enhancement, and immune modulation. Scientific studies have demonstrated ashwagandha's ability to decrease cortisol levels, improve cognitive function, increase energy levels, and modulate immune function. One study showed that administration of ashwagandha (as Noogandha) at 225gm or 400gm, supplement daily resulted in improvements in the physiological, cognitive, and psychological stress response over a 30-day period (2). Compared to traditional ashwagandha supplements, NooGanda's liposomal formulation may provide superior benefits due to enhanced absorption and bioavailability.

Stress Reduction and Relaxation

Stress has been linked to various health-related consequences, such as declining cognitive abilities, heightened mood disturbances like depression and anxiety, and an elevated risk of developing specific chronic illnesses. Ashwagandha has been shown to reduce stress and promote relaxation by lowering cortisol levels and modulating stress-related biomarkers. NooGanda's liposomal formulation may offer superior stress-relieving effects compared to conventional ashwagandha supplements due to its enhanced bioavailability, allowing for more efficient delivery of active compounds to target tissues. 

Cognitive Support and Mental Clarity

Emerging research suggests that ashwagandha may support cognitive function, memory, and mental clarity. NooGanda's liposomal delivery system enhances the absorption of ashwagandha, potentially leading to improved cognitive benefits compared to traditional supplements. A double-blind placebo-controlled crossover study found NooGandha can improve acute cognitive performance, including sustained attention, prevention of mental fatigue, increased short-term memory and improved response/reaction time (indicating low mental fatigue), with a single 400 mg dose (4). 

Energy Boost and Vitality

Ashwagandha has a long history of use in traditional medicine for its ability to enhance vitality, energy, endurance and stamina, attributed to the adaptogenic properties of the herb (2,4). NooGanda's liposomal formulation provides a convenient and efficient way to boost energy and stamina, supporting overall well-being.

Immune Modulation and Wellness

Research shows that ashwagandha significantly improved the immune profile of healthy subjects by modulating the innate and adaptive immune systems, by increasing T-cell proliferation and enhancing macrophages functions (1,3). NooGanda's liposomal delivery system optimizes the absorption of ashwagandha, potentially enhancing its ability to modulate immune function and promote overall wellness.

Safety and Considerations

Ashwagandha is generally considered safe for most people when taken at recommended doses. However, individuals with certain medical conditions or those taking medications should consult with a healthcare professional before using ashwagandha or NooGanda. Side effects are rare but may include gastrointestinal upset or allergic reactions. Proper dosage and usage guidelines should be followed to ensure safety and efficacy.

Conclusion

NooGanda's innovative liposomal delivery system enhances the absorption and bioavailability of ashwagandha, leading to superior therapeutic effects. With scientific research highlighting the benefits, ranging from improved cognitive support, mental clarity, increased energy, stress reduction and immune modulation, NooGanda offers a comprehensive solution for promoting overall health and vitality. Easily taken as a one or two dose, with minimal sedative impact, consider incorporating NooGanda into your daily wellness routine to experience the full potential of ashwagandha.



Written by, Lyndall Wright.

References

1.Alanazi, H. H., & Elfaki, E. (2023). The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1084757

2.Remenapp, A., Coyle, K., Orange, T., Lynch, T., Hooper, D., Hooper, S., Conway, K., & Hausenblas, H. A. (2022). Efficacy of Withania somnifera supplementation on adult’s cognition and mood. Journal of Ayurveda and Integrative Medicine, 13(2), 100510. https://doi.org/10.1016/j.jaim.2021.08.003

3.Tharakan, A., Shukla, H., Benny, I. R., Tharakan, M., George, L., & Koshy, S. (2021). Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Journal of Clinical Medicine, 10(16), 3644. https://doi.org/10.3390/jcm10163644

4.Xing, D., Yoo, C., Gonzalez, D., Jenkins, V., Nottingham, K., Dickerson, B., Leonard, M., Ko, J., Faries, M., Kephart, W., Purpura, M., Jäger, R., Sowinski, R., Rasmussen, C. J., & Kreider, R. B. (2022). Effects of Acute Ashwagandha Ingestion on Cognitive Function. International Journal of Environmental Research and Public Health, 19(19), 11852. https://doi.org/10.3390/ijerph191911852

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