Introduction
Vascular health is a fundamental aspect of overall wellbeing, as it ensures efficient blood circulation and supports heart function, influencing various physiological processes while playing a critical role in the prevention of numerous cardiovascular diseases.
The vascular system, also referred to as the circulatory system, comprises of the heart, arteries, veins and capillaries, and serves as the body’s network for transporting oxygen, nutrients and waste products to and from tissues and organs.
The vascular system is a complex network of blood vessels crucial for circulation in the body. Arteries carry oxygenated blood from the heart to various tissues, dividing into large and small arteries. Large arteries experiencing high pressure are thicker and elastic to manage this pressure. Smaller arteries contain more smooth muscle, regulating blood flow to specific body areas by contracting or relaxing. While veins return deoxygenated blood back to the heart. Capillaries, the smallest blood vessels, facilitates nutrient and waste exchange between blood and tissues.
Factors Affecting Vascular Health
Maintaining vascular health through lifestyle choices like regular exercise, a balanced diet, avoiding smoking and managing stress is essential for optimal health. Diet significantly influences vascular health by affecting factors such as blood pressure, cholesterol levels, inflammation, and oxidative stress, all of which can either promote or reduce the development of vascular diseases. Physical activity may not only play a role in preventing vascular injury but could also serve as a therapeutic focus even during the early phases of vascular disease. Smoking has been associated with brain vascular changes.
Hypertension, high cholesterol, and diabetes pose significant risks to vascular health by damaging blood vessel walls, promoting the accumulation of plaque, and impeding blood flow. If these conditions are left untreated, they may lead to atherosclerosis, peripheral artery disease, and other vascular complications, underscoring the critical need for effective management strategies to safeguard vascular health and alleviate associated risks.
Key Nutrients for Vascular Health
The Synergistic Effects of Vitamins D3 and K2
Vitamins D3 and K2 are essential nutrients that play critical roles in maintaining vascular health, particularly in the prevention of vascular calcification and the enhancement of overall cardiovascular function.
Vitamin D3 is crucial in regulating calcium levels within the bloodstream. This regulation is vital because it helps prevent the undesirable deposition of calcium on the walls of blood vessels, a process known as vascular calcification. Such calcifications can lead to atherosclerosis, a condition characterised by the hardening and narrowing of the arteries, which significantly increases the risk of heart disease.
Furthermore, vitamin D3 is implicated in the modulation of blood pressure and the improvement of endothelial function. The endothelium plays a fundamental role in vascular health by controlling the dilation and constriction of blood vessels, thereby regulating blood pressure.
Vitamin K2's primary function in vascular health is the activation of proteins that regulate calcium deposition in the body. It activates matrix Gla protein (MGP), which is one of the most potent inhibitors of arterial calcification. By ensuring calcium is prevented from building up in artery walls, vitamin K2 helps maintain the flexibility and integrity of blood vessels.
Additionally, vitamin K2 contributes to the elasticity of blood vessel walls by aiding in the synthesis of other proteins responsible for maintaining the structure of soft tissues. This action helps to reduce the stiffness of vessels, a common factor in cardiovascular risk.
The cooperative action between the two vitamins is crucial for preventing calcification in the arteries, thus reducing the risk of atherosclerosis and subsequent cardiovascular diseases.
Liposomal D3 and K2
Liposomal formulation of vitamins D3 and K2 offer enhanced absorption and bioavailability compared to conventional supplements. This advanced delivery system ensures more efficient utilisation of essential vitamins in the body and supporting vascular health. With targeted delivery to tissues, liposomal D3 and K2 provide a convenient and effective means of supplementation.
Encapsulation in liposomes enhances absorption and bioavailability ensuring that more of these nutrients reach the bloodstream intact. This improved absorption means that lower doses can often achieve the same therapeutic effects as higher doses of non-encapsulated forms. Additionally, the lipid bilayer of liposomes facilitates the targeted delivery of D3 and K2 to tissues throughout the body to maximise their health benefits. Therefore, liposomal D3 and K2 represent an effective and efficient way to supplement these essential vitamins.
Ubiquinol – The Active form of CoQ10
Ubiquinol is the active form of Coenzyme Q10 (CoQ10) and is an essential component in the maintenance of vascular health through its involvement in several key biological processes.
One of the primary roles of ubiquinol is its function as a potent antioxidant. In the vascular system, the presence of oxidative stress can lead to damage and disease, notably atherosclerosis, where arteries become clogged and hardened. Ubiquinol combats this by neutralising free radicals, thus protecting the endothelial cells lining the blood vessels from oxidative damage. This antioxidant action helps to preserve the integrity and functionality of the cardiovascular system, preventing the progression of vascular diseases.
Ubiquinol is also critical for the production of energy in cells, particularly in the mitochondria, the powerhouse of the cell. In the heart and vascular system, energy demand is high, and efficient energy production is crucial for maintaining optimal function. Ubiquinol facilitates the production of ATP, the energy currency of the cell, ensuring that heart and vascular tissues have adequate energy to perform their vital functions. This not only supports the heart's pumping action but also aids the smooth muscles in the vascular walls to maintain blood vessel tone and flexibility.
Ubiquinol has also been shown to lower inflammation in the body by reducing inflammatory markers. This anti-inflammatory action can help in mitigating the chronic inflammation seen in the vascular walls, which often leads to complications if left unaddressed.
Finally, ubiquinol improves endothelial function, which is critical in maintaining vascular health. The endothelium regulates various aspects of vascular function, including the dilation and constriction of blood vessels, blood clotting, and immune function. By improving endothelial function, ubiquinol helps in maintaining proper blood flow and vascular responsiveness, which are essential for preventing conditions such as hypertension and vascular calcification.
Beetroot for Vascular Health
Beetroot’s nitrate content proves significant in vascular health, as nitrate conversion to nitric oxide facilitates endothelial function, blood pressure regulation, and blood flow improvement.
The nitrate rich composition of beetroot promotes the production of nitric oxide, a key vasodilator. Nitric oxide synthesis leads to widened blood vessels, enhancing blood flow and reducing peripheral resistance, which subsequently lowers blood pressure.
With beetroot supplementation, individuals can harness these benefits to potentially reduce cardiovascular risks. By enhancing oxygen and nutrient delivery to the brain, beetroot-derived nitric oxide may contribute to improved vascular health.
Conclusion
Maintaining vascular health is crucial for overall health, ensuring efficient blood circulation, heart function and preventing cardiovascular diseases. Vitamins such as D3, K2, ubiquinol and beetroot concentrate supplements offer comprehensive support. Liposomal D3 and K2 enhance absorption and regulate calcium levels, preventing arterial calcification and atherosclerosis. Ubiquinol, the active form of CoQ10, is a potent antioxidant that optimises cellular energy metabolism and protects against oxidative damage. Beetroot’s nitrate content promotes nitric oxide production, enhancing endothelial function and blood flow regulation. Together, these supplements provide a holistic approach to improve vascular health, supporting longevity and quality of life.
Written by Toni Horsford.
References:
Abdellatif, M., Sedcej, S., Gutierrez, D.C., Madeo, F., & Kroemer, G. (2018). Autophagy in Cardiocascular Aging. Circulation Research. 123(7), 803-824. Doi doi.org/10.1161/CIRCRESAHA.118.312208
Chaudhry, R., Miao, J.H., & Rehman, A. (2022). Physiology, Cardiovascular. StatPearls Publishing; Jan 2024. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK493197/
Crintea, A., Dutu, A.G., Sovrea, A., Constantin, A.M., Samasca, G., Masalar, A.L., Ifju, B., Linga, E., Neamti, L., Tranca, R.A., Fekete, Z., Silaghi, C.N., & Cranciun, A.M. (2022). Nanocarriers for Drug Delivery: An Overview with Emphasis on Vitamin D and K Transportation. Nanomaterials. 12(8), 1376. Doi: doi.org/10.3390/nano12081376
Daniells, S. (2023). Chewable beetroot supplement may boost cognition, memory: Human data. Nutra Ingredients Europe. Retrieved from: https://www.nutraingredients.com/Article/2023/12/04/chewable-beetroot-supplement-may-boost-cognition-memory-human-data#
Gottesman, R.F., & Seshadri, S. (2022). Risk Factors, Lifestyle Behaviors, and Vascular Health Brain Health. Stroke. 53(2), 394-403. Doi: doi.org/10.1161/STROKEAHA.121.032610
Norman, P.E., & Powell, J.T. (2014). Vitamin D and Cardiovascular Disease. Circulation Research. 114(2), 379-393. Doi: doi.org/10.1161/CIRCRESAHA.113.301241
Pierce, J.D., Mahoney, D.E., Hiebert, J.B., Thimmesch, A.R., Diaz, F.J., Smith, C., Shen, Q., Mudaranthakam, D.P., & Clancy, R.L. (2018). Study protocol, randomized controlled trial: reducing symptom burden in patients with heart failure with preserved ejection fraction using ubiquinol and/or D-ribose. BMC Cardiovascular Disorders. 18,(57), 2018. doi.org/10.1186/s12872-018-0796-2
Pre Lab Pro®. (2021). RedNite Beetroot Powder Nitrate Content: Turbocharge Your Workout. Retrieved from: https://www.prelabpro.com/blogs/nutrition/rednite-beetroot-powder-nitrate-content
Sood, B., Patel, P., Keenaghan, M. (2024). Coenzyme Q10. Statpearls Publishing. Jan 2024. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK531491/
Vaccaro, M.G., Innocenti, B., Cione, E., De Sarro, G., Bonilla, D.A., & Cannataro, R. (2024). Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial. European Journal of Nutrition. 63, 303–321 (2024). Doi: doi.org/10.1007/s00394-023-03265-y Epub 2023 Oct 24. PMID: 37875637; PMCID: PMC10799154.
Leave a comment
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.